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ANTARCTIC: platelet function testing to adjust therapy …

We read the ANTARCTIC study by Guillaume Cayla and colleagues1 with interest. The authors interpreted that platelet function monitoring with treatment adjustment did not improve the clinical outcome of elderly patients treated with coronary stenting for an acute coronary syndrome. We think that the following granular conclusion is more appropriate: elderly patients with acute coronary syndrome ...

Platelet function tests for monitoring antiplatelet agent therapy

Platelet function testing • Traditionally done to identify congenital and acquired platelet function defects • Traditionally considered qualitative testing requiring interpretation in the context patient condition • Multiple method exist • Each measures slightly different

Platelet function during pregnancy: an evaluation using …

In clinical practice, the only tests of platelet function are bleeding time and platelet number. Bleeding time lacks sensitivity and specificity but the PFA-100, an in vitro analyser of platelet function may be of value. This study aimed to evaluate any correlation between platelet number and function using the PFA-100 in pregnant women. During a 21-month period, platelet function was ...

Platelet Function During Extended Prasugrel and …

Context The relationship of platelet function testing measurements with outcomes in patients with acute coronary syndromes (ACS) initially managed medically without revascularization is unknown. Objective To characterize the differences and evaluate clinical outcomes associated with platelet reactivity among patients with ACS treated with clopidogrel or prasugrel.

Platelets Facilitate the Wound-Healing Capability of …

Platelet-Derived mitochondria Display embryonic stem cell markers and improve pancreatic islet β-cell function in humans. Stem Cells Transl. Med. 2017; 6 : 1684-1697 Crossref

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Standard- vs high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: the GRAVITAS randomized trial. JAMA. 2011;305:1097e1105. 9. Collet JP, Cuisset T, Range G, et al, Investigators A. Bedside monitoring to adjust 10.

Applied Nursing Research

use of platelet function test results to guide the timing of surgery in patients receiving Plavix and other platelet inhibitors prior to coronary artery bypass graft (CABG) and valve replacement.

ANTARCTIC: platelet function testing to adjust therapy

We carefully read the ANTARCTIC study by Guillaume Cayla and colleagues (Oct 22, p 2015),1 and would like to suggest a different interpretation of the results. The trial studied the utility of platelet function reactivity (assessed by VerifyNow) guidance in elderly ...

Platelet function in baboons and humans — A comparative study of whole blood using impedance platelet …

Platelet function testing is essential to diagnose inherited and ac-quired platelet disorders [10,11]. Among the various techniques to de-tect and monitor platelet reactivity, impedance ...

Platelet Aggregation Test: Purpose, Procedure, and Risks

Platelet aggregation test A platelet aggregation test checks how well your platelets clump together to form blood clots. Platelets are a type of blood cell. They help form blood clots by sticking ...

Platelets

37. Platelet Function Testing in Clinical Research Trials Andrew L. Frelinger, III PART IV: Disorders of Platelet Number and/or Function 38. The Clinical Approach to Disorders of Platelet Number and Function Alan D. Michelson 39. Immune Thrombocytopenia (ITP)

ScienceDirect | Science, health and medical journals, …

 · Platelet function testing was performed using VerifyNow, which is maintained in our central hematology laboratory for quality assurance. In addition, there was a 6-month time frame in which we collected clopidogrel cytochrome 2C19 (CYP2C19) genotype to distinguish metabolic activity (Verigene CYP2C19 nucleic acid test by Nanosphere, Inc., Northbrook, Illinois, USA).

AN IN-VITRO STUDY OF ACIDOSIS, PLATELET FUNCTION, …

Platelet aggregation in response to adenosine diphosphate was studied in umbilical-vein blood from 24 term infants. The pH of platelet-rich plasma was experimentally reduced by adding increasing concentrations of lactic acid or by exposure to carbon dioxide. Aggregation was significantly impaired by acidosis and there was a significant positive correlation between falling pH and impaired ...

Platelet Function Testing: Dead or Alive | PracticeUpdate

Platelet Function Testing: Dead or Alive Journal of Thrombosis and Haemostasis (JTH) Save Recommend Share Facebook Twitter LinkedIn Print Email × You must be a member to content. Already Have An Account? Log in Now ...

The Platelet And Platelet Function Testing In Liver Disease

About Low Platelet: The Platelet And Platelet Function Testing In Liver Disease. Low Platelet Info, Remedies that will help your low platelets. This article shares a brief overview of the Brain which excreted via the blood cells. Unfortunately the the platelet and platelet function testing in liver disease aim is to recover complete with white cell that not only are performed lovastatin a ...

Platelet function testing during 5-day storage of single and …

 · Using aggregometer, a traditional way of in vivo platelet function testing, we found that aggregation responses of the platelets prepared by either RDP or SDP method decreased significantly from the 1st day to the 5th day of the storage process.

Platelets and platelet function testing in children

Platelets play key roles in hemostasis as well as in the pathogenesis of arterial thrombosis. This review summarizes current knowledge of the physiolo…

Clinical Tests of Platelet Function

 · Platelet function testing began with the application of the in vivo bleeding time by Duke in 1910. 12 The technique consists of inflicting a small incision in the skin of the forearm or the earlobe, and recording the time required for a clot to form at the site of the incision and stop the flow of blood.

Platelet Protocols

Platelet Protocols fills the need for a straightforward and comprehensive laboratory manual on current procedures for evaluating and analyzing platelet function and abnormalities. It is an easy-to-read, understandable resource which can be kept at the bench and referred to frequently by scientists, clinicians, and laboratory staff involved in platelet related areas.

Platelet aggregometry assay for evaluating the effects of platelet agonists and antiplatelet compounds on platelet function …

Method Article Platelet aggregometry assay for evaluating the effects of platelet agonists and antiplatelet compounds on platelet function in vitro Alexandros Tsoupras1, Ioannis Zabetakis1, Ronan ...

Dual antiplatelet therapy guided by platelet function …

Standard- vs high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: the GRAVITAS randomized trial. JAMA. 2011; 305 : 1097-1105 View in Article

Preoperative Point-of-Care Platelet Function Testing in …

To investigate if the use of preoperative platelet function testing (PFT) as part of a transfusion algorithm reduced blood product usage in coronary artery bypass surgery (CABG). Design Prospective, randomized, controlled trial.

Platelets

View on ScienceDirect Platelets 3rd Edition Editor: Alan Michelson Hardcover ISBN: 9780123878373 eBook ISBN: 9780123878380 ... IV Use of Platelet Function Testing in the Clinical Setting V Summary and the Future of Platelet Function Testing References ...

10 Platelet Aggregation Test Factors You Must Know

 · Platelet Function Testing Is Commonly Performed in Patients with Known Confounding Factors. 6. How to prepare for the test There are some medications that can affect the results of a platelet aggregation test. Make sure to let your healthcare provider know ...

COMPARISON OF TWO DIFFERENT METHODS TO …

PURPOSE: Emerging data suggest that many patients are non responsive or only partially responsive to antiplatelet therapy. Different methods have been described to identify such patients. Traditionally light transmission aggregometry (LTA) is considered the gold standard. Helena Laboratories ICHOR/ Plateletworks® is a useful point of care test, based on platelet counts and provides a rapid ...

Dual antiplatelet therapy guided by platelet function …

Dual antiplatelet therapy guided by platelet function testing Creator: University of Florida College of Medicine-Jacksonville, Jacksonville, FL 32209, USA ( host institution) Angiolillo, Dominick J ( UF author) Affiliation: University of Florida College of Medicine